Two McNeill branches in West Virginia

Has anyone determined if there's a close connection between John McNeill, born 1721 in Frederick Co., VA, m. Elizabeth Van Meter, and my ancestor, John McNeill, born 1680 Coleraine, Northern Ireland, m. Elizabeth McNealus in Philadelphia?

The first John and his descendants settled in Pocahontas County, West Virginia while the second John and his descendants settled in Hardy County, West Virginia.

The family of the first John's wife, Van Meter, might be connected to the Van Meters of Hardy County, some of whom married Hardy County McNeill descendants.